The Technology, Leadership and Strategy Initiative is co-chaired by:
- Dr. Klaus Hoehn, Vice President of Advanced Technology and Engineering for Deere & Company
- Dr. Ray Johnson, Senior Vice President and Chief Technology Officer for Lockheed Martin Corporation
- Dr. Mark M. Little, Senior Vice President and Director of Global Research for the General Electric Company
Additionally, TLSI operates four Working Groups:
- Accelerating Innovation Working Group: aims to improve the movement of ideas from laboratory to market
- Regulation and Policy Working Group: aims to establish more coherent federal laws and regulations that make commercialization less expensive, better incentivized and more strategic
- Talent Working Group: aims to develop, attract and retain world class scientific and technical talent for the United States
- Innovation Outreach Working Group: aims to "tell the innovation story" more effectively to key audiences, particularly policymakers, students and the American public

