Researchers at the Salk Institute are using supercomputers at the nearby NSF-funded San Diego Supercomputer Center to investigate how the synapses of the brain work. Their research has the potential to help people suffering from mental disorders such as Alzheimer’s, schizophrenia and manic depressive disorders. In addition, the use of supercomputers is helping to change the very nature of biology—from a science that has relied primarily on observation to a science that relies on high performance computing to achieve previously impossible in-depth quantitative results.